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Abu-Amer Lab - Publications
  1. Abu-Amer, Y. and Bar-Shavit, Z. Modulation of vitamin D increased H2O2 production and MAC-2 expression in bone marrow-derived macrophages by estrogen.  Calcif. Tissue Int. 55:29-32, 1994.  PMID: 7922786
  2. Abu-Amer, Y. and Bar-Shavit, Z. Regulation of TNF-a release from bone marrow-derived macrophages by vitamin D.  J. Cell. Biochem. 55:435-444, 1994.  PMID: 7962175
  3. Teitelbaum, S.L., Abu-Amer, Y., and Ross, F. P. Molecular mechanisms of bone resorption.  J. Cell. Biochem. 59:1-10, 1995.  PMID: 8530528
  4. Matayoshi, A., Brown, C., Di Persio, J., Haug, J., Abu-Amer, Y., Liapis, H., Kuestner, R., and Pacifici, R. Human blood-mobilized hematopoietic precursors differentiate into osteoclasts in the absence of stromal cells. Proc. Natl. Acad. Sci. 93(20):10785-10790, 1996.  PMID: 8855258
  5. Abu-Amer, Y., Ross, F.P., Schlesinger, P., Tondravi, M.M., and Teitelbaum, S.L. Substrate recognition by osteoclast precursors induces c-src/microtubule association.  J. Cell Biol. 137(1): 247-258, 1997.  PMID: 9105052
  6. Abu-Amer, Y., Ross, F.P., Edwards, J., Teitelbaum,S.L. Lipopolysaccharide-stimulated osteoclastogenesis is mediated by tumor necrosis factor via its p55 receptor. J.Clin.Inves. 100(6):1557-1565, 1997.  PMID: 9294124
  7. Abu-Amer, Y., and MM. Tondravi. NF-kB and bone: The breaking point. Nature Medicine 11(3),pp 1189-1190, 1997.  PMID: 9359684
  8. Chappel J., F. P. Ross, Y. Abu-Amer, A. Shaw and S. L. Teitelbaum. 1,25-dihydroxyvitamin D3 regulates pp60c-src activity and expression of a pp60c-src activating phosphatase. J. Cell. Biochem. 67(4):432-438, 1997.  PMID: 9383703
  9. Abu-Amer, Y., Ross, F.P., McHugh, K., Livolsi A., Peyron J-F., and Teitelbaum, S.L. TNF activation of NF-kB in marrow macrophages is mediated by c-src tyrosine phosphorylation of IkB. J. Biol. Chem. 273(45): 29417-29423, 1998.  PMID: 9792645
  10. Abu-Amer, Y., Teitelbaum, S.L., and Ross, F.P.  Expression and regulation of rab3 proteins in osteoclasts and their precursors. JBMR 14 (11), 1855-1860, 1999.  PMID: 10571685
  11. Merkel, K.D., Erdmann, J.M., McHugh, K.P., Abu-Amer, Y., Ross, F.P., and Teitelbaum,S.L. Tumor necrosis factor alpha mediates implant osteolysis via its p55 receptor. Am. J. Pathol. 154, 203-210, 1999.  PMID: 9916934
  12. Adams, A.E., Stueckle, S., Abu-Amer, Y., Ross, F.P., Teitelbaum, S.L., and Suva, L.J. 1,25(OH)2D3  and dexamethasone induce cyclooxygenase-1 but not cyclooxygenase-2 expression by osteoclastogenic    stromal cells. J. Cell. Biochem. 74:587-595, 1999.  PMID: 10440928
  13. Huang Z., Ritter C., Brown A., Finch J., Abu-Amer Y. and E. Slatopolsky. Cloning and Localization of Rab3 Isoforms in Bovine, Rat, and Human Parathyroid Glands. Biochem. Biophys. Res. Comm. 255, 645-651, 1999.  PMID: 10049764
  14. Mbalaviele G., Abu-Amer Y., Meng A., Jaiswal R., Beck S., Pittenger M., Theide M. and D Marshak. Activation of PPAR-gamma Pathway Inhibits Osteoclast Differentiation. . J. Biol. Chem. 275(19),14388-14393,2000.  PMID: 10799521
  15. Inoue M., FP. Ross, J. Erdmann, Y. Abu-Amer, and SL. Teitelbaum. TNF regulates avb5 integrin expression by osteoclast precursors in vitro and in vivo. Endocrinology 141(1):284-90,2000.  PMID: 10614649
  16. Abu-Amer, Y., J. Erdmann, Alexopoulou L., Kollias, G., S.L. Teitelbaum. Tumor Necrosis Factor Receptors Type 1 and  2 Differentially Regulate Osteoclastogenesis. J. Biol. Chem. 275(35):27307-27310,2000.  PMID: 10874036
  17. Zhang Y-H., Huelsmann A., Tondravi M., Mukhrejee A. and Y. Abu-Amer. Tumor necrosis factor-alpha stimulates RANKL-induced osteoclast recruitment via coupling TNF receptor-1 and RANK signaling pathways. J Biol. Chem. 276(1):563-568,2001.   PMID: 11032840
  18. Abu-Amer, Y., Interleukin-4 abrogates osteoclastogenesis by mechanisms involving STAT6 inhibition of NF-kB transactivation. J.Clin Invest. 107:1375-1385, 2001.  PMID: 11390419
  19. Abu-Amer, Y., Dowdy SF., Zhang Y-H., Ross FP., Clohisy JC., SL. Teitelbaum. TAT fusion proteins containing tyrosine-42-deleted IkBa arrest osteoclastogenesis. J Biol. Chem. 276:30499-30503, 2001.  PMID: 11408488
  20. Clohisy JC., Teitelbaum SL., Chen S., Erdmann J. and Y. Abu-Amer. Tumor necrosis factor-alpha mediates polymethylmethacrylate particle-induced NF-kB activation in osteoclast precursor cells. J. Orthop. Res. 20:174-181, 2002.  PMID: 11918294
  21. Gupta A, Lee BS, Khadeer MA, Tang Z, Chellaiah M, Abu-Amer Y, Goldknopf J, Hruska KA.. Leupaxin is a linker protein in the clear zone of the osteoclast. J. Bone Min. Res. 18(4):669-85, 2003.   PMID: 12675328
  22. Clohisy JC., Fraizer E., Hirayama T., and Y. Abu-Amer. RANKL is an essential cytokine mediator of polymethylmethacrylate particle-induced osteoclastogenesis. J. Ortho. Res. 21(2):202-212, 2003.  PMID: 12568950
  23. Lam J., Abu-Amer, Y., Nelson CA., Fermont D., Ross FP., Teitelbaum SL. Tumor necrosis superfamily cytokines and pathogenesis of inflammatory osteolysis. Annals of Rheumatic Diseases. 61:82-83, 2002.  PMID: 12379631
  24. Abu-Amer Y: Mechanisms of Inflammatory Mediators in Bone Loss Diseases, in Rosier RN, Evans CH (eds): Molecular Biology in Orthopaedics, Rosemont, IL, American Academy of Orthopaedic Surgeons, 2003, pp 229-239.
  25. Khan, E. and Y. Abu-Amer. Activation of  PPAR-gamma inhibits differentiation of pre-osteoblasts. J. Lab. Clin. Med. 142:29-34, 2003.  PMID: 12878983
  26. Abbas S. and Y. Abu-Amer,. Dominant-negative IkB facilitates apoptosis of osteoclasts by tumor necrosis factor. J. Biol. Chem. 278: 20077 – 20082, 2003.  PMID: 12637573
  27. Abbas S., Zhang Y-H., Clohisy JC., and Y. Abu-Amer. Tumor necrosis factor-alpha inhibits pre-osteoblast differentiation through its type-1 receptor. Cytokine 22:33-41, 2003.  PMID: 12946103
  28. Abbas S., Clohisy JC., Y. Abu-Amer. Mitogen-activated protein kinases mediate PMMA-induction of osteoclasts. J. Ortho. Res. 21:1041-1048, 2003.  PMID: 14554217
  29. Clohisy JC., Biondo C., Roy B., Willis D., Teitelbaum SL., Y. Abu-Amer. Direct inhibition of NF-kB blocks bone erosion associated with inflammatory arthritis. J. Immunol. 171:5547-5553, 2003.  PMID: 14607962
  30. Abu-Amer, Y. and JC Clohisy. Biologic response to orthopedic implants, in Einhorn T., O’Keefe R., and Buckwalter J (eds): Orthopedic Basic Science, ed 3. American Academy of Orthopaedic Surgeons, 2007, pp 365-377.
  31. Clohisy JC., Hirayama T., Frazier E., Han S., Y Abu-Amer. NF-kB signaling blockade abolishes implant particle-induced osteoclastogenesis. J. Ortho. Res., 22(1):13-20, 2004.  PMID: 14656654
  32. Abu-Amer, Y., Abbas, S., Hirayama, T. TNFr1 regulates RANKL expression by stromal cells and modulates osteoclastogenesis. J. Cell. Biochem. 93:980-989, 2004.  PMID: 15389885
  33. Dai S., Hirayama, T., Abbas, S. and Y. Abu-Amer. The IKK inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis. J. Biol. Chem.; 279: 37219 – 37222, 2004  PMID: 15252035
  34. Kitaura H., Sands M., Aya K., Zhou P., Hirayama T., Utugennant B., Takeshita S., Silva M., Abu-Amer, Y., Ross FP., SL. Teitelbaum. Marrow stromal cells and osteoclast precursors differentially contribute to TNF-alpha-induced osteoclastogenesis in vivo. J. Immunol. 173: 4838 – 4846, 2004.  PMID: 15470024
  35. Silva MJ., Brodt MD., Ko M., and Y. Abu-Amer. Impaired Marrow Osteogenesis is Associated with Reduced Endocortical Bone Formation But Does Not Impair Periosteal Bone Formation in Long Bones of SAMP6 Mice. J. Bone Min. Res. 20:419-427, 2005.  PMID: 15746986
  36. Abu-Amer, Y. Advances in Osteoclast Differentiation and Function. Curr Drug Targets Immune Endocr Metabol Disord:5:347-55; 2005.  PMID: 16178795
  37. Hirayama, T., Dai S., Abbas, S., Yamanaka, Y., and Y. Abu-Amer. Constitutively active STAT6 inhibits osteoclastogenesis and inflammatory bone destruction through blockade of JNK activation. Arth. Rheum.:52:2719-2729; 2005.  PMID: 16142755
  38. Mbalaviele G, Anderson GD, Jones AL, De Ciechi P, Settle SL, Mnich sJ, Thiede MA, Abu-Amer Y,  Portanova J, and Monahan JB. Inhibition of p38 mapk prevents inflammatory bone destruction. J Pharmacol Exp Ther 2006; 317:1044-53.  PMID: 16501068
  39. Yamanaka, Y; Abu-Amer, Y; Faccio, R; Clohisy, JC. The map kinase c-jun n-terminal kinase mediates PMMA-induction of osteoclasts. J Orthop Res 2006; 24:1349-57.  PMID: 16732613
  40. Clohisy JC, Yamanaka Y, Faccio R, and Y. Abu-Amer. Inhibition of IKK activation, through sequestering NEMO, blocks PMMA-induced osteoclastogenesis and calvarial inflammatory osteolysis. J Orthop Res. 2006 Jul;24(7):1358-65.  PMID: 16705717
  41. Abu-Amer Y and R. Faccio. Therapeutic approaches in bone pathogenesis: targeting the IKK/NF-kB axis. Future Rheumatol. Vol 1,133-146, 2006
  42. Dufort FJ, Bleiman BF, Gumina MR, Blair D, Wagner DJ, Roberts MF, Abu-Amer Y, and Chiles TC.
  43. Cutting Edge: IL-4-Mediated Protection of Primary B Lymphocytes from Apoptosis via Stat6-Dependent Regulation of Glycolytic Metabolism. J. Immunol., 2007; 179: 4953 - 4957.
  44. Kiesel, J., Miller, C, Abu-Amer, Y., and R. Aurora. Systems level analysis of osteoclastogenesis reveals intrinsic and extrinsic regulatory interactions. Developmental Dynamics. 236:2181-97, 2007.
  45. Abu-Amer, Y., Darwech I., and JC. Clohisy. Aseptic Loosening of Total Joint Replacements: mechanisms underlying osteolysis and potential therapies. Arthritis Research & Therapy Vol. 9 (Suppl 1), S6, 2007.
  46. Abu-Amer, Yousef; Darwech, Isra and Otero, Jesse (September 2007) Osteoporosis and Osteopetrosis. In: ENCYCLOPEDIA OF LIFE SCIENCES. John Wiley & Sons, Ltd: Chichester http://www.els.net/ [DOI: 10.1002/9780470015902.a0006017]
  47. Abu-Amer, Yousef; Darwech, Isra and Otero, Jesse. Role of the NF-kB axis in immune modulation of osteoclasts and bone loss. Autoimmunity 8:1-8, 2007. [DOI: 10.1080/08916930701694543]
  48. Yamanaka, Y., Abu-Amer, W., Foglia, D., Otero, JE., Clohisy, JC., and Y.  Abu-Amer. NFAT2 Is An Essential Mediator Of Orthopedic Particle-Induced Osteoclastogenesis. JOR, in press 2008

 

Yousef Abu-Amer, Ph.D

Associate Professor

Department of Orthopaedics

Washington University

abuamery@wustl.edu

Yalem Building 822

Phone: (314) 362-8597 



  

 
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