R01 054326
7/08-7/13
Agency: NIH/NIAMS
Role: PI
Title: Mechanisms of IKK regulation of basal and inflammatory osteoclastogenesis
Goals: determine the molecular role of IKK1 and IKK2 in basal and inflammatory osteoclastogenesis, and regulation of IKK activity in inflammatory osteolysis.
R01 049192
3/04-3/09
Agency: NIH/NIAMS
Role: PI
Title: Mechanisms of implant- induced osteolysis.
Goals: 1) Delineate the mechanism by which PMMA particles activate MAP kinase pathways in osteoclast precursors. 2) Inhibit inflammatory osteolysis, in vivo, by blocking PMMA particle-induced p38 and Erk1/2 activation.
Biomedical Research Grant
1/07-1/09
Agency: Shriners Hospital for Children
Role: PI
Title: Regulation of Erosive Inflammatory Arthritis by IKKs.
Goal: investigate the role of IKKs in regulation of inflammatory cytokines.
Biomedical Research Grant
1/08-1/11
Agency: Shriners Hospital for Children
Role: PI
Title: Regulation of bone erosion relevant to JRA
Goal: Investigate mechanisms of bone erosion in young mouse model of serum transfer-induced arthritis.
OREF Career Development Award
7/1/05-6/30/07
Agency: AAOS
Role: Co-I
Goals: Investigate molecular role of RANKL in osteolysis.
R01
10/06-10/10
Agency: NIH/NIAMS
Role: Co-I
Type: R01
Tittle: Regulatory Pathways in Osteoclast Formation and Function.
Goals: determine the role of PLC?2 and its various domains in osteoclastogenesis and inflammatory osteolysis
Completed (Last 3 years):
R01 DE013754
8/99 - 8/04
Role: PI
Agency: NIH/NIDCR
Title: Mechanisms of TNF Receptor-Mediated Osteoclastogenesis.
Goals: to investigate the relative roles of TNF receptors 1 and 2 in basal and cytokine-induced osteoclastogenesis.
R01 AR47443
9/02-9/06
Role: PI
Agency: NIH/NIAMS
Title: Regulatory Mechanisms of Inflammatory Osteolysis.
Goals: 1) determine the mechanisms by which TNFr1 signaling pathway stimulates RANKL-mediated osteoclastogenesis. 2) Determine the mechanisms by which IL-4 inhibits basal and acute osteoclastogenesis.
Biomedical Research grant
1/01-1/07
Agency: Shriners Hospital for Children
Role: PI
Title: Regulation of bone erosion relevant to JRA
Goal: Investigate mechanisms of bone erosion in young mouse model of serum transfer-induced arthritis.