Washington University in St. Louis School of Medicine
Washington University: Department of Orthopaedic Surgery
Washington University Orthopedics
Thomopoulos Lab - Publications
  1. Carpenter JE, Flanagan CL, Thomopoulos S, Yian EH, Soslowsky LJ.  The effects of overuse combined with intrinsic or extrinsic alterations in an animal model of rotator cuff tendinosis.  American Journal of Sports Medicine, 26:801-807, 1998. [Pubmed]
  2. Carpenter JE, Thomopoulos S, Flanagan CL, DeBano CM, Soslowsky LJ.  Rotator cuff defect healing: A biomechanical and histological analysis in an animal model.  Journal of Shoulder and Elbow Surgery, 7:599-605, 1998[Pubmed]
  3. Carpenter JE, Thomopoulos S, Soslowsky LJ.  Animal models of tendon and ligament injuries for tissue engineering.  Clinical Orthopaedics and Related Research, 367:S296-S311, 1999. [Pubmed]
  4. Soslowsky LJ, Thomopoulos S, Tun S, Flanagan CL, Keefer CC, Mastaw J, Carpenter JE.  Overuse activity injures the supraspinatus tendon in an animal model: A histologic and biomechanical study.  Journal of Shoulder and Elbow Surgery, 9:79-84, 2000. [Pubmed]
  5. Thomopoulos S, Hattersley G, Rosen V, Mertens M, Galatz L, Williams GR, Soslowsky LJ.  The localized expression of extracellular matrix components in healing tendon insertion sites: An in situ hybridization study.  Journal of Orthopaedic Research, 20:454-463, 2002. [Pubmed]
  6. Thomopoulos S, Soslowsky LJ, Flanagan CL, Tun S, Keefer CC, Mastaw J, Carpenter JE.  The effect of fibrin clot on healing rat supraspinatus tendon defects.  Journal of Shoulder and Elbow Surgery, 11:239-47, 2002. [Pubmed]
  7. Soslowsky LJ, Thomopoulos S, Esmail A, Williamson II JD, Flanagan CL, Iannotti JP, Carpenter JE.  Rotator cuff tendinosis in an animal model: The role of extrinsic and overuse factors. Annals of Biomedical Engineering, 30:1057-1063, 2002. [Pubmed]
  8. Thomopoulos S, Williams G, Soslowsky LJ.  Tendon-to-bone healing: Differences in biomechanical, structural, and compositional properties due to a range of activity level.  Journal of Biomechanical Engineering, 125:106-113, 2003. [Pubmed]
  9. Thomopoulos S, Williams GR, Gimbel JA, Favata M, Soslowsky LJ.  Variation of biomechanical, structural, and compositional properties along the tendon-to-bone insertion site.  Journal of Orthopaedic Research, 21:413-419, 2003. [Pubmed]
  10. Thomopoulos S, Harwood FL, Silva MJ, Amiel D, Gelberman RH. Effect of several growth factors on canine tendon fibroblast proliferation and collagen synthesis in vitro. Journal of Hand Surgery - American, 30:441-447, 2005. [Pubmed]
  11. Thomopoulos S, Fomovsky G, Holmes JW. The development of structural and mechanical anisotropy in fibroblast populated collagen gels.  Journal of Biomechanical Engineering, 127:742-750, 2005.  [Pubmed]
  12. Galatz LM, Rothermich SY, Zaegel M, Silva MJ, Havlioglu N, Thomopoulos S. Delayed repair of tendon-to-bone injuries leads to decreased biomechanical properties and bone loss. Journal of Orthopaedic Research, 23:1441-7, 2005. [Pubmed]
  13. Silva MJ, Brodt MD, Wopenka B, Thomopoulos S, Williams D, Ko M, Kusano N, Mecham RP, Bank R. Decreased collagen organization and content are associated with reduced material strength of demineralized and intact bone in the SAMP6 murine model of senile osteoporosis. Journal of Bone and Mineral Research, 21:78-88, 2006. [Pubmed]
  14. Galatz LM, Sandell LJ, Rothermich SY, Das R, Mastny A, Havlioglu N, Silva M, Thomopoulos S. Characteristics of the rat supraspinatus tendon during tendon-to-bone healing after acute injury. Journal of Orthopaedic Research, 24(3):541-550, 2006. [Pubmed]
  15. Silva MJ, Thomopoulos S, Kusano N, Zaegel MA, Harwood FL, Matsuzaki H,  Havlioglu N, Dovan TT, Amiel D, Gelberman RH. Early healing of flexor tendon insertion site injuries:  tunnel repair is mechanically and histologically inferior to surface repair in a canine model. Journal of Orthopaedic Research, 24(5):990-1000, 2006. [Pubmed]
  16. Thomopoulos S, Marquez JP, Weinberger B, Birman V, Genin GM. Collagen fiber orientation at the tendon-to-bone insertion and its influence on stress concentrations. Journal of Biomechanics, 39(10):1842-1851, 2006. [Pubmed]
  17. Galatz LM, Silva MJ, Rothermich SY, Zaegel MA, Havioglu N, Thomopoulos S. Nicotine delays tendon-to-bone healing in a rat shoulder model. Journal of Bone and Joint Surgery [American], 88(9):2027-34, 2006. [Pubmed]
  18. Thomopoulos S, Matsuzaki H, Zaegel M, Gelberman RH, Silva MJ. Alendronate prevents bone loss and improves tendon-to-bone repair strength in a canine model. Journal of Orthopaedic Research, 25(4):473-479, 2007. [Pubmed]
  19. Gelberman RH, Thomopoulos S, Sakiyama-Elbert S, Das R, Silva M. The early effects of sustained platelet derived growth factor administration on the functional and structural properties of repaired intrasynovial flexor tendons: An in vivo biomechanical study at the three week interval in canines. Journal of Hand Surgery – American, 32(3):373-9, 2007. [Pubmed]
  20. Gimbel JA, Van Kleunen JP, Williams GR, Thomopoulos S, Soslowsky LJ. Long durations of immobilization may be necessary to enhance the mechanical properties of the healing supraspinatus tendon. Journal of Biomechanical Engineering, 129(3):400-404, 2007. [Pubmed]
  21. Thomopoulos S, Kim HM, Rothermich SY, Biederstadt C, Das R. Galatz LM. Decreased muscle loading delays maturation of the tendon enthesis during post-natal development. Journal of Orthopaedic Research, 25(9), 1154-1163, 2007. [Pubmed]
  22. Thomopoulos S, Zaegel M, Das R, Harwood FL, Silva MJ, Amiel D, Sakiyama-Elbert S, Gelberman RH. PDGF-BB released in tendon repair using a novel delivery system promotes cell proliferation and collagen remodeling. Journal of Orthopaedic Research, 25(10):1358-1368, 2007. [Pubmed]
  23. Thomopoulos S, Fomovsky G, Chandran PL, Holmes JW. Collagen fiber alignment does not explain mechanical anisotropy in fibroblast populated collagen gels. Journal of Biomechanical Engineering, 129(5):642-650, 2007. [Pubmed]
  24. Galatz LM, Rothermich SY, VanderPloeg KA, Petersen BC, Sandell LJ, Thomopoulos S. Development of the supraspinatus tendon-to-bone insertion: localized expression of extracellular matrix and growth factor genes. Journal of Orthopaedic Research, 25(12):1621-1628, 2007. [Pubmed]
  25. Sakiyama-Elbert S, Das R, Gelberman RH, Harwood F, Amiel D, Thomopoulos S. Controlled release kinetics and biologic activity of PDGF-BB for use in flexor tendon repair. Journal of Hand Surgery [American], 33(9):1548-57, 2008. [Pubmed]

  26. Thomopoulos S, Zampiakis E, Das R, Silva MJ, Gelberman RH. The effect of muscle loading on flexor tendon-to-bone healing in a canine model. Journal of Orthopaedic Research, 26(12):1611-1617, 2008. [Pubmed]

  27. Wopenka B, Kent A, Pasteris JD, Yoon Y, Thomopoulos S. The tendon-to-bone transition of the rotator cuff: A preliminary Raman spectroscopic study documenting the gradual mineralization across the insertion in tissue samples of rats. Applied Spectroscopy, 62(12):1285-1294, 2008. [Pubmed]

  28. Kim HM, Galatz L, Patel N, Das R, Thomopoulos S. Recovery potential after postnatal shoulder paralysis: An animal model of neonatal brachial plexus palsy. Journal Journal of Bone and Joint Surgery [American], 91:879-891, 2009. [Pubmed]

  29. Thomopoulos S, Das R, Silva MJ, Sakiyama-Elbert S, Harwood FL, Zampiakis E, Kim HM, Amiel D, Gelberman RH. Enhanced flexor tendon healing through sustained delivery of PDGF-BB. Journal of Orthopaedic Research, 27(9):1209-15, 2009. [Pubmed]

  30. Galatz LM, Charlton N, Das R, Kim HM, Havlioglu N, Thomopoulos S. Complete removal of load is detrimental to rotator cuff healing. Journal of Shoulder and Elbow Surgery, 18(5)669-675, 2009. [Pubmed]

  31. Thomopoulos S, Zampiakis E, Das R, Kim HM, Silva MJ, Havlioglu N, Gelberman RH. The use of a magnesium-based bone adhesive for flexor tendon-to-bone healing. Journal of Hand Surgery [American], 34(6):1066-73, 2009. [Pubmed]

  32. Genin GM, Kent A, Birman V, Wopenka B, Pasteris JD, Marquez JP, Thomopoulos S. Functional grading of mineral and collagen in the attachment of tendon to bone. Biophysical Journal, 97(4):976-985, 2009. [Pubmed]

  33. Fomovsky GM, Thomopoulos S, Jeffrey W. Holmes. Contribution of extracellular matrix to the mechanical properties of the heart. Journal of Molecular and Cellular Cardiology, Epub ahead of print, 2009. [Pubmed]

  34. Li X, Xie J, Lipner J, Yuan X, Thomopoulos S*, Xia Y*. Nanofiber scaffolds with gradations in mineral content for mimicking the tendon-to-bone insertion site. Nano Letters, 9(7):2763-8, 2009. [Note: shared senior/corresponding authorship for Thomopoulos and Xia]. [Pubmed]

     

Book Chapters

  1. Thomopoulos S. Tendons and Ligaments. In: Orthopaedic Board Review Manual: Basic Science. Eds: Clohisy J and Grauer J, American Academy of Orthopaedic Surgeons, Rosemont IL, 2007.
  2. Thomopoulos S. Basic Science Considerations in Rotator Cuff. In: Orthopaedic Knowledge Update: Shoulder and Elbow 3. Eds: Galatz L and Lee TQ, American Academy of Orthopaedic Surgeons, Rosemont IL, 2007.
  3. Thomopoulos S. Research Trends for Flexor Tendon Repair. In: Biomaterials in Hand Surgery. Eds: Merolli A and Joyce T, Springet-Verlag, 2009.

 

Stavros Thomopoulos, Ph.D

Assistant Professor

Department of Orthopaedics

Washington University

thomopouloss@wustl.edu

Yalem Building 812

Phone: (314) 362-8597 



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