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Silva Lab - Publications
  1. Silva MJ, Brodt MD, Wopenka B, Thomopoulos S, Williams DE, Wassen MH, Ko M, Kusano N, Bank RA. Decreased collagen organization and content are associated with reduced material strength of demineralized and intact bone in the SAMP6 mouse.  J Bone Miner Res, 21: 78-88, 2006.
  2. Silva MJ, Thomopoulos S, Kusano N, Zaegel MA, Harwood FL, Matsuzaki H, Havlioglu N, Dovan TT, Amiel D, Gelberman R. Early healing of flexor tendon insertion site injuries: Tunnel repair is mechanically and histologically inferior to surface repair in a canine model.  J. Orthop. Res., 24(5): 990-1000, 2006.
  3. Silva MJ, Uthgenannt BA, Rutlin JR, Wohl GR, Lewis JS, Welch MJ. In vivo skeletal imaging of 18F-fluoride with positron emission tomography reveals damage- and time-dependent responses to fatigue loading in the rat ulna. Bone, 39(2):229-36, 2006.
  4. Christiansen BA, Silva MJ.  The Effect of Varying Magnitudes of Whole-Body Vibration on Several Skeletal Sites in Mice. Ann Biomed Eng. 34(7):1149-56, 2006.
  5. Thomopoulos S, Matsuzaki H, Zaegel M, Gelberman RH, Silva MJ. Alendronate prevents bone loss and improves tendon to bone repair strength in a canine model. J Orthop Res, 25(4):473-9, 2007.
  6. Uthgenannt BA, Silva MJ.  Use of the rat forelimb compression model to create discrete levels of bone damage in vivo. J Biomech, 40(2):317-24, 2007.
  7. Gelberman RH, Thomopoulos S, Sakiyama-Elbert SE, Das R, Silva MJ. The early effects of sustained platelet-derived growth factor administration on the functional and structural properties of repaired intrasynovial flexor tendons: an in vivo biomechanic study at 3 weeks in canines. J Hand Surg [Am] 32(3):373-9, 2007.
  8. Matsuzaki H, Wohl GR, Novack DV, Lynch JA, Silva MJ. Damaging Fatigue Loading Stimulates Rapid Increases in Vascularity at Sites of Bone Formation in the Rat Ulna. Calcif Tiss Int, 80(6):391-9, 2007. 
  9. Uthgenannt BA, Kramer MH, Hwu JA, Wopenka B, Silva MJ. Skeletal Self-Repair: Stress Fracture Healing by Rapid Formation and Densification of Woven Bone. J Bone Miner Res, 22(10): 1548-56, 2007.
  10. Grimston SK, Brodt MD, Silva MJ, Civitelli R.  Attenuated Response to in vivo Mechanical Loading in Mice with Conditional Osteoblast Ablation of the Connexin43 Gene (Gja1). J Bone Miner Res, Jun;23(6):879-86, 2008.
  11. Ramanadham S, Yarasheski KE, Silva MJ, Wohltmann M, Veis-Novack D, Christiansen B, Lei X, Turk J. Age-Related Changes in Bone Morphology are Accelerated in Group VIA Calcium-Independent Phospholipase A2b (iPLA2b)-Null Mice. Am. J. Pathology, 172(4):868-81, 2008.
  12. Lynch JA, Silva MJ. In Vivo Static Creep Loading of the Rat Forelimb Reduces Ulnar Structural Properties at Time-Zero and Induces Damage-Dependent Woven Bone Formation. Bone, 42(5):942-9, 2008.
  13. Christiansen BA, Bayly PV, Silva MJ. Constrained Tibial Vibration in Mice: A Method for Studying the Effects of Vibrational Loading of Bone. J Biomech. Engr., 130(4):044502:1-6, 2008.
  14. Thomopoulos S, Zampiakis E, Das R, Silva MJ, Gelberman RH. The Effect of Muscle Loading on Flexor Tendon-to-Bone Healing in a Canine Model. J Orthop Res, 26(12):1611-7, 2008.
  15. Silva MJ, Brodt MD. Mechanical Stimulation of Bone Formation is Normal in the SAMP6 Mouse. Calcif. Tiss. Int., 82(6):489-97, 2008. [doi: 10.1007/s00223-008-9142-5]
  16. Baumgarten KM, Brodt MD, Wright RW, Silva MJ. An in vitro analysis of the mechanical properties of 16 arthroscopic knots.  Knee Surg Sports Traumatol Arthrosc, Oct;16(10):957-66, 2008. 
  17. Reich MS, Jarvis JP, Silva MJ, Cheverud.J. Genetic Relationships between Obesity and Osteoporosis in LGXSM Recombinant Inbred Mice. Genetics Research, 90(5):433-44, 2008.
  18. Wohl GR, Towler DA, Silva MJ. Stress Fracture Healing: Fatigue Loading of the Rat Ulna Induces Upregulation in Expression of Osteogenic and Angiogenic Genes that Mimic the Intramembranous Portion of Fracture Repair. Bone, 44(2):320-330, 2009. [doi:10.1016/j.bone.2008.09.010]
  19. Borrelli J, Silva MJ, Zaegel MA, Franz C, Sandell LJ. A Single High Energy Impact Load Causes Posttraumatic OA in Young Rabbits Via A Decrease in Cellular Metabolism. J. Orthop. Res, 2008 Oct 15. [Epub]; 27(3):347-352, 2009.
  20. Thomopoulos S, Das R, Silva MJ, Sakiyama-Elbert S, Harwood FL, Zampiakis E, Kim HM, Amiel D, Gelberman RH. Enhanced flexor tendon healing through controlled delivery of PDGF-BB. J. Orthop. Res., Accepted, Feb. 2009.
  21. Silva MJ, Brodt MD, Lynch MA, McKenzie JA, Tanouye KM, Nyman J, Wang X.  Type 1 Diabetes in Young Rats Leads to Progressive Trabecular Bone Loss, Cessation of Cortical Bone Growth and Diminished Whole-Bone Strength and Fatigue Life.  J. Bone Miner. Res., Accepted, Mar 2009.
  22. Thomopoulos S, Zampiakis E, Das R, Kim HM, Silva MJ, Havlioglu N, Gelberman RH. The use of a magnesium-based bone adhesive for flexor tendon-to-bone healing. J. Hand Surg. [Am], Accepted, April 2009.

Matthew Silva, Ph.D

Professor

Department of Orthopaedics

Washington University

silvam@wustl.edu

Yalem Building 812

Phone: (314) 362-8597 
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