“Response of the Osteoporotic Skeleton to Mechanical Loading”

Role: Principal Investigator,  Agency: NIH/NIAMS;   R01 AR47867, July 2001 - May 2010

Assess the response of the aged/osteoporotic skeleton to mechanical loading in mice.

“Stimulating Bone Formation using Constrained Tibial Vibration”

Role: Principal Investigator,  Agency: NIH/NIAMS;  R21 AR054371 Sept. 2007 – July 2009

Examine effects of vibrational stimuli on bone formation, molecular transport, and gene expression.

“Genetic Environmental Relationships Between Bone, Obesity and Leptin in Mice”

Role: Co-Investigator (PI: J Cheverud); NIH/NIDDK R01 DK075112; April 2006 – March 2011 

Map gene effects on bone mass, morphology, and strength; relates bone properties and obesity.

“Flexor Tendon Healing”

Role: Co-Investigator, (PI: RH Gelberman); NIH/NIAMS R01 AR33097; April 2000 – March 2011

Improve flexor tendon healing by in vivo delivery of growth factors.

“FGFs in skeletal development, vasculogenesis and repair”

Role: Co-Investigator (PI: D Ornitz); NIH/NICHD; R01 HD049808; Aug. 2006 – May 2011

Determine roles of FGF2, 9 and 18 in skeletal development, fracture repair, and response to skeletal loading.

“Connexin 43 in Bone Formation”

Role: Co-Investigator (PI: R Civitelli); NIH/NIAMS R01AR041255; Sept. 2007 – Aug. 2012

Determine role of connexin 43 in bone formation, in particular in loading-induced bone formation.

“Notch Signaling and Bone Formation”

Role: Co-Investigator (PI: F. Long); NIH/NIAMS R01AR055923; 2008-2013