Selected peer-reviewed publications (last four years)

1. Huang, Z., Xu, H., & Sandell, L. J.  Negative Regulation of Chondrocyte Differentiation by Transcription Factor AP2a.  J Bone and Mineral Res, 19(2): 245-55. 2004.
2. Gurley, J. M., Wamsley, M. S. & Sandell, L. J.  Alternations in Apoptosis and Epithelial-mesenchymal Transformation in an in vitro Cleft Palate Model.  Plastic Recon Surg, 113(3):907-14. 2004.
3. Rousseau, J. C., Sandell, L. J., Delmas, P. D., and Garnero, P.  Development and clinical Application in Arthritis of a New Immunoassay for Serum Type IIA Procollagen NH2 Propeptide.  Meth Mol Med 101:25-37. 2004 .
4. Rousseau, J. C., Zhu, Y., Miossec, P., Vignon, E., Sandell, L. J., Garnero, P., & Delmas, P. D.  Serum Levels of Type IIA Procollagen Amino Terminal Propeptide (PIIANP) are Decreased in Patients with Knee Osteoarthritis and Rheumatoid Arthritis.  Osteoarthritis and Cartilage 12(6): 440-7. 2004.
5. Davies, S.R., Li, J., Okazaki, K. & Sandell, L. J.  Differential Regulation of the Cdrap Gene Within a Conserved, Multigenic Housekeeping Locus. Genomics 83(4): 667-78. 2004.
6. Borrelli J, Zhu Y, Burns M, Sandell L. J., Silva M. J.  Cartilage Tolerates Single Impact Loads Up to Half of the Joint Fracture Threshold.  Clin Orthop 426: 266-73. 2004
7. O’Leary, JM, Hamilton, JM., Deane, CM, Valeyen, NV., Sandell, L. J. and Downing, AK.  Solution Structure and Dynamics of a Prototypical Chordin-like Cysteine-rich Repeat (von Willebrand Factor Type C Module) form Collagen IIA.  J. Biol. Chem., 279: 53857-53866. 2004.
8. Imamura, T., Imamura, C., Iwamoto, Y., and Sandell, L. J.  Transcriptional co-activator CBP/p300 increase chondrocyte Cd-rap gene expression by multiple mechanisms including sequestration of the repressor CCAAT/enhancer-binding protein.  J Biol Chem., 280:16625-16634. 2005.
9. El-Zawawy, H., Silva, M, Sandell, L. J. and Wright, R.  Ligamentous versus physeal failure in murine medial collateral ligament biomechanical testing., J Biomechan.  38(4): 703-6.  2005.
10. Pietka, T.A., Sandell., L.J., Charni, N., Ryan, R., Mistry, J and Garnero, P.  Development of a New Enzyme Immunoassay (EIA) for Serum Type IIA Collagen N-propeptide (PIIANP) and Evaluation in Patients with Rheumatoid Arthritis.  Ann Rheum. Dis. 64:1906. 2005.
11. McAlinden, A., Havlioglu, N., Liang, L., Davies, SD and Sandell, L. J.  Alternative splicing of type II procollagen exon 2 is regulated by the combination of a weak 5' splice site and an adjacent intronic stem-loop cis element.  J. Biol. Chem. 280:32700-32711. 2005.
12. Posey, K.L., Davies, S., Bales E.S., Haynes, R., Sandell, L. J. and Hetch J.T.  In vivo human Cartilage Oligometric Matrix Protein (COMP) promoter activity. Matrix Biol. 24(8):539-49. 2005,
13. Okazaki, K., Davies, SR, Imamura, T., and Sandell, L. J.  A Promoter Element Of The Cd-Rap Gene Is
14.      Required For Repression Of Gene Expression In Non-Cartilage Tissues In Vitro And In Vivo"  J. Cell. Biochem. 97(4): 857-68.  2006.         
15. Galatz, L.M., Sandell., J.L., Rothermilch, S.Y., Das, R., Mastny, A., Havlioglu, N., Silva, M.J. and Thomopoulos, S.  Characteristics of the rat supraspinatus tendon during tendon-to-bone healing after acute injury.  J Orthopaedic Res 24(3): 541-50. 2006. 
16. El-Zawawy, H., Gill, C. Wright, R., and Sandell, L. J.  Smoking Delays Chondrogenesis in a mouse model of closed tibial fracture healing., J Orthopaedic Res 24:2150-2158. 2006.
17. Wright, R., Allen, T., El-Zawawy., Brodt, M., Silva, M., Gill, C., Sandell, L.J., Medial collateral ligament healing in macrophage metalloelastase (MMP-12)-deficient mice. J Orthopaedic Res 24(11): 2106-13. 2006.
18. Fukui, N., Ikeda, Y., Ohnuki, T., Hikita, A., Tanaka, S., Yamane, S., Suzuki,R., Sandell, L.J., and Ochi, T., Pro-inflammatory cytokine tumor necrosis factor-a induces bone morphogenetic protein-2 in chondrocytes via mRNA stabilization and transcriptional up-regulation. J Biol Chem. 281:27229-27241. 2006.
19. Gill, C., Sandell., J. L., Hossam, E., Wright, R., Effect of Cigarette smoking on early medial collateral ligament healing in a mouse model., J Orthopaedic Res.  24 (12):2141-9. 2006.
20. Davies, S., Chang, L., Patra, D., Xing, X., Stokes, D., Posey, K., Hecht, J., Stormo, G., and Sandell, L.J.
21.      Computational Identification of Regulatory Motifs in Cartilage Expressed Genes. Genome Res. 17: 1438-1447. 2007.
22. McAlinden, A., Liang, L., Mukudai,Y., Imamura,T., and Sandell, L. J.  Nuclear Protein TIA-1 Regulates Alternative Splicing by Interaction with Genomic DNA and Precursor mRNA. J Biol Chem. 282: 24444-24454. 2007.
23. Patra, D., Xing, X., Davies, S., Bryan, J., and  Sandell, L. J.  Lack of Endochondral Ossification in Site-1 Protease Knockout Mouse. J. Cell Biol. 179: 687-700. 2007.
24. Sharif, M, Kirwan, J., Charni, N., Sandell, L. J.,  Whittles, C., and Garnero,P., A 5-yr Longitundinal Study of Type IIA Collagen Synthesis and Total Type II Collagen Degradation in Patients with Knee Osteoarthrits- Association with Disease Progression. Rheumatology 46:938-943. 2007.
25. Jones, K., Sponseller, P., Erkula, G., Sakai, L., Ramirez, F., Dietz, H., Kost-Byerly, S., Bridwell,K., Sandell, L. J. Symposium on the Musculoskeletal Aspects of Marfan Syndrome: Meeting Report and State of the Science. J Orthop Res 25(3): 413-22.  2007.
26. Bay-Jensen, A.C., Andersen, T., Tabassi, N., Kristensen, P., Kjaersgaard-Andersen, P., Sandell, L.J., Garnero, P., Delaisse, J., Biochemical Markers of Type II Collagen Breakdown and Synthesis are Positioned at Specific Sites in Human Osteoarthritic Knee Cartilage.  Osteoarthritis and Cartilage 10:1016 -1021. 2007.
27. Fukui, N., Ikeda, Y., Ohnuki, T., Tanaka, Hikita, A., Mitomi, H., Mori, T., Juji, T., Katsuragawa, Y., Yamamoto, S., Sawabe, M., Yamane, S., S., Suzuki,R., Sandell, L.J.,  and Ochi, T., Regional Differences in Chondrocyte Metabolism in Osteoarthritis,  Arthr Rheum 58 (1): 154-163. 2008.

28. Bay-Jensen, A.C., Andersen, T., Tabassi, N., Kristensen, P., Kjaersgaard-Andersen, P., Sandell, L.J., Garnero, P., Delaisse, J., Biochemical markers of type II collagen breakdown and synthesis are positioned at specific sites in human osteoarthritic knee cartilage.  Osteoarthritis and Cartilage May 16 (5): 615 -623. 2008.

29. Imamura, T., Imamura, C., McAlinden, A., Davies, S., Iwamoto, Y.  Sandell, L.J.  A novel tumor necrosis factor-a responsive CCAAT/enhancer-binding protein site regulates cartilage Cd-Rap expression.  Arthr Rheum Apr 58(5): 1366-1376. 2008.

30. Khan, I., Gilbert, S., Caterson,B., Sandell, L. J., Archer, C., Oxidative stress induces expression of osteoarthritis markers procollagen IIA and 3b3(-) in adult bovine articular cartilage. Osteoarthritis and Cartilage 16(6): 698-707; 2008.

31. Borrelli, J., Silva, M., Zaegel, M., Franz, C. and Sandell, L.J.  A single high energy impact load causes post-traumatic osteoarthritis in young rabbits. J Orthop Res, (in press).

32. Sandell, L.J., Xiaoyun,X., Franz, C., Davies, S., Chang, L., and Patra, D., Exuberrant expression of chemokine genes by adult human articular chondrocytes in response to IL-1ß. Osteoarthritis and Cartilage Jun 2008.

33. Rich, J., Rosova, I., Nolta, J., Myckatyn, T., Sandell, L.J., McAlinden, A., Upregulation of runx2 and osterix during in vitro chondrogenesis of human adipose-derived stromal cells. Biochem and Biophys Res Comm, 372(1); 230-5; 2008

Reviews and Book Chapters (selected recent)

1. Sandell, L. J. and Towler, D.  Transcription of Bone and Cartilage Genes.  Curr Opin Orthop 13:375-381, 2002.
2. Li, J. and Sandell, L.J. Transcriptional Regulation of Cartilage-specific Genes in Chondrogenesis.  Pp. 21-34 in Rosier, R. and Evan, C.H., Eds. Molecular Biology in Orthopaedics.  American Association of Orthopaedic Surgeons Press, Rosemont, IL. Pp 21-34 2003.
3. Sandell, L. J. and Okazaki, K. Overview of Connective Tissue Genes: Extracellular Matrix Gene Regulation In Future Directions on Osteoarthritis Research, Clinical Ortho and Rel Res, 427 Supl; S123-128. 2004.
4. McAlinden, A., Havlioglu, N and Sandell, L. J. Regulation of Protein Diversity by Alternative Pre mRNA Splicing with Specific Focus on Chondrogenesis. Birth Defects Res C Embryo Today, 72(1): 51-68. 2004.
5. Sandell, L.J., Bone Morphogenetic Protein and Transforming Growth Factor- ß Interactions with Extracellular Matrix in Health and Disease., Curr Opin Orthop 17:412-417. Lippincott Williams & Wilkins 2006.
6. Sandell, L. J.  Molecular Aspects of Cartilage Repair. Cells Tissues Organs (in press).
7. Fukui, N and Sandell, L.J.  Anabolic Aspects of Cartilage Repair in Topics in Bone Biology, Vol. 4.  Bone and Osteoarthritis, Bronner, F. and Farach-Carson, M.C., eds, Springer-Verlag, 97-108, 2007.
8. Sandell, L.J., Hering, T., and Heinegard, D. Cell Biology,Biochemistry and Molecular and Cell Biology of Articular Cartilage in Osteoarthritis in Osteoarthritis, 4^th Edition, Moskowitz, R, ed.  (4): 73-106. 2007. 
9. Sandell, L. J. Modern Molecular Analysis of a Traditional Disease: Progression in Osteoarthritis. Arthr Rheum, 56 (8): 2474-7. 2007.
10. Sandell, L. J. Anabolic Factors in Degenerative Joint Disease. Curr Drug Targets., 8(2): 359-65. 2007.
11. Goldring, M. and Sandell, L. J.  Transcriptional Control of Chondrocyte Gene Expression. In Osteoarthritis, Inflammation and Degradation: A Continuum.  Buckwalter, J., Lotz, M. and Stoltz, J.-F  IOS Press, Biomedical and Health Research, 70:118-142. 2007.

Books

1. Sandell, L.J. and Grodzinsky, A. (eds.).  Clinical Applications of Tissue Engineering in Musculoskeletal Diseases, American Academy of Orthopaedic Surgeons Press, Rosemont, IL, 2004.