CURRENT RESEARCH SUPPORT
R01 AR36994 Sandell (PI)
9/01/2005– 08/31/2010
NIH/NIAMS
“Regulation of Gene Expression in Cartilage”
The specific aims of this study are to 1) investigate the role of negative transcription factors during chondrogenesis, specifically ap-2, ?ef-1 and c/ebp.; 2) investigate the regulation of the type ii procollagen pre-mRNA alternative splicing switch that occurs during chondrogenesis. 3) determine the function of developmentally-expressed type IIA procollagen protein isoform in vivo. 4) investigate the mechanism of IL-1ß and TNF-a induction of BMP-2 in adult chondrocytes.
R01 AR 05554 Sandell (PI)
2/1/2004-1/31/2009
NIH/NIAMS
“Function and Regulation of CD-RAP”
The specific aims of this study are to: 1) determine the mechanism of the CD-RAP 183-bp regulatory domain that confers tissue specificity; 2) determine the role of additional negative/positive regulatory elements; 3) screen for and analyze co-regulators; 4) computational identification and functional validation of novel regulatory motifs.
R01 AR 053224 Cheverud (PI); Sandell (Co-investigator)
7/01/2006 – 6/30/2011
NIH
“ Genetic Variation in Murine Long Bone Growth and Development”
The goal of this project is to determine the genes that cause bone growth.
05-015 Silva (PI); Sandell (Co-investigator)
7/01/2008 – 6/30/2009
Orthopaedic Research and Education Foundation
“In Vivo Cartilage Changes after Mechanic Insult”
330556423 8/1/08 to 7/31/09
Siteman Cancer Center
Research Development Award in Developmental Therapeutics
“Novel Treatment for Breast Cancer with Chondrostatin”
COMPLETED
PS 1032-02 Sandell (PI)
01/01/2005 – 12/31/2006
Pfizer Inc.
Osteoarthritis Collagen II Biomarker development and Clinical Evaluation
R01 AR36994 Sandell (PI)
9/01/2001– 08/31/2005
NIH/NIAMS
“Regulation of Gene Expression in Cartilage”
R01 AR 05554 Sandell (PI)
2/1/1999-1/31/2004
NIH/NIAMS
“Function and Regulation of CD-RAP”