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Faccio Lab - Publications
  1. M Grano, R Faccio, S Colucci, R Paniccia, N Baldini, A Zambonin Zallone, A Teti: Extracellular Ca2+-sensing is modulated by pH in human osteoclast-like cells in vitro.  Am J Physiol 1994, 267:C961­C968. PMID: 7943292.
  2. S Colucci, G Giannelli, M Grano, R Faccio, V Quaranta, A Zambonin Zallone: Human Osteoclast-like cells                  selectively recognize laminin isoforms, an event that induces migration and activates Ca2+ mediated signals.  J Cell Science 1996, 109:1527-1535. PMID: 8799839
  3. R Faccio, M Grano, S Colucci, A Zambonin Zallone, V Quaranta, AJ Pelletier: Activation of avb3 integrin on human osteoclast-like cells stimulates adhesion and migration in response to osteopontin.  Biochem & Biophys Res Comm 1998, 249 2:522-525. PMID: 9712729
  4. A Zallone, R Faccio, G Zambonin: I Bisfosfonati: gruppi di molecole con diversi effetti intracellulari e applicazioni cliniche.  Update on Bisfosfonati 1999 6,1:3-7.
  5. R Monno, G Grandaliano, R Faccio, E Ranieri, C Martino, L Gesualdo, FP Schena: Activated Coagulation Factor X: a novel mitogenic stimulus for human mesangial cells. J Am Soc Nephrol. 2001, 12: 891-9. PMID: 11316847
  6. X Feng, DV Novack, R Faccio, DS Ory, K Aya, MI Boyer, KP McHugh, FP Ross, SL Teitelbaum: A Glanzmann’s mutation in beta3 integrin specifically impairs osteoclast function. J Clin Invest 2001,   107:1137-44. PMID: 11342577
  7. R. Faccio, M. Grano, S. Colucci, A. Villa, G.Giannelli, V. Quaranta and A. Zallone. Localization and possible role of two different avb3 integrin conformations in resting and resorbing osteoclasts. J Cell Science 2002, 115:2919-2929. PMID: 12082152
  8. R Faccio, S Takeshita, A Zallone, FP Ross, SL Teitelbaum. c-Fms and the alpha(v)beta(3) integrin collaborate during osteoclast differentiation. J Clin Invest. 2003, 111(5):749-58. PMID: 12618529
  9. R Faccio, DV Novack, A Zallone, FP Ross, SL Teitelbaum. Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by ß3 integrin. J Cell Biol 2003, 162(3):499-509. PMID: 12900398
  10. R Faccio, W Zou, G Colaianni, SL Teitelbaum, FP Ross. High dose M-CSF partially rescues the Dap12 -/- osteoclast phenotype. J Cell Biochem, 2003 90 (5): 871-883. PMID: 14624447
  11. K Fujikawa, AV Miletic, FW Alt, R Faccio, T Brown, J Hoog, J Fredericks, S Nishi, S Mildiner, SL Moores,      J Brugge, FS Rosen, W Swat. Vav1/2/3-null mice define an essential role for Vav Family Proteins in Lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells. J Exp Med, 2003 198(10):1595-1608. PMID: 14623913
  12. MWH Wang, S Wei, R Faccio, S Takeshita, P Tebas, WG Powderly, SL Teitelbaum, FP Ross. The HIV protease inhibitor Ritonavir inhibits osteoclast differentiation and function by impairing RANKL-induced NF-kB and AKT signaling. J Clin Invest 2004 114(2):206-13. PMID: 15254587
  13. S Colucci, G Brunetti, R Rizzi, A Zonno, G Mori, G Colaianni, D Del Prete, R Faccio, A Liso, S Capalbo, V Liso, A Zallone, M Grano. T cells support osteoclastogenesis in an in vitro model derived from human       multiple myeloma bone disease: the role of the OPG/Trail interaction. Blood. 2004 104(12):3722-30. PMID: 15308561
  14. R Faccio, SL Teitelbaum, K Fujikawa, J Chappel, A Zallone, V L Tybulewicz, FP Ross and W Swat. Vav3 regulates osteoclast function and bone mass. Nature Medicine 2005 11(3):284-90. PMID: 15711558
  15. S Tehrani, R Faccio, I Candrasekar, FP Ross, JA Cooper. Cortactin has an essential and specific role in osteoclast actin assembly. Mol Biol Cell. 2006 17(7):2882-95. PMID: 16611741
  16. Y Yamanaka, Y Abu-Amer, R Faccio, J Clohisy. The MAP-kinase c-Jun N terminal kinase mediates PMMA-induction of osteoclasts. J Orthop Res. 2006 24(7):1349-57. PMID: 16732613
  17. J Clohisy. Y Yamanaka, R Faccio Y Abu-Amer. Inhibition of IKK activation through sequestering NEMO, blocks PMMA-induced osteoclastogenesis and calvarial inflammatory osteolysis. J Orthop Res. 2006 24(7):1358-65. PMID: 16705717
  18. LK Myers, SD Bhattacharya, PA Herring, Z Xing, S Goorha, RA Smith, SK Bhattacharya, L Carbone, R Faccio, AK Kang, LR Ballou. The isozyme-specific effects of cyclooxygenase-deficiency on bone in mice. Bone. 2006 39(5):1048-52. PMID: 16875891
  19. D. Mao, H. Epple, B. Uthgenannt, D.V. Novack, R. Faccio. PLC?2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2. JCI 2006 116(11):2869-79. PMID: 17053833
  20. Y. Feng, H. Zhao, H. F. Luderer, H. Epple, R. Faccio, F. P. Ross, S. L. Teitelbaum, and G. D. Longmore. The LIM protein, Limd1, regulates AP-1 activation through an interaction with Traf6 to influence osteoclast development. J Biol Chem. 2007 282(1):39-48. PMID: 17092936
  21. N. Napoli, R. Faccio, V. Shrestha, S. Bucchieri, G.B. Rini, R. Armamento-Villareal. Estrogen metabolism modulates bone density in men. Calcif Tissue Int. 2007 80(4):227-32. PMID: 17406768
  22. R. Faccio, S. Takeshita, G. Colaianni, J. Chappel, A. Zallone, S.L. Teitelbaum, and F.P. Ross. M-CSF regulates the cytoskeleton via recruitment of a multimeric signaling complex to c-Fms Y559/697/721. J Biol Chem. 2007 Jun 29;282(26):18991-9. PMID: 17420256
  23. S. Takeshita,  R. Faccio, J. Chappel, L. Zheng, X. Feng, J.D. Weber, S.L. Teitelbaum, and F.P. Ross. c-Fms Y559 is a major mediator of M-CSF induced proliferation of primary macrophages. J Biol Chem 2007 Jun 29;282(26):18980-90. PMID: 17420255
  24. D.B. Graham, C.M Robertson, J. Bautista, F. Mascarenhas, M.J. Diacovo, V. Montgrain, S.K. Lam, V. Cremasco, W.M. Dunne, R. Faccio, C.M. Coopersmith, W. Swat. Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice. J Clin Invest. 2007 Nov;117(11):3445-52. PMID: 17932569
  25. D. Daria, M.D. Filippi, E.S. Knudsen, R. Faccio, Z. Li, T. Kalfa, H. Geiger. The retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stress. Blood Dec 2007 – on line.
  26. D. Daria, M.D. Filippi, E.S. Knudsen, R. Faccio, Z. Li, T. Kalfa, H. Geiger. The retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stress. Blood. 2008 Feb 15;111(4):1894-902.
  27. S. Vaira, T.  Johnson, A.C. Hirbe, M. Alhawagri, I. Anwisye, B. Sammut, J. O’Neal, W. Zou, K.N. Weilbaecher, R. Faccio, and D.V. Novack.  RelB is the NF-?B subunit downstream of NIK responsible for osteoclast differentiation.  Proc. Natl. Acad. Sci (2008)., 105:3897-3902. PMID: 18322009.
  28. S. Vaira, M. Alhawagri, I. Anwisye, H. Kitaura, R. Faccio, and D.V. Novack.  RANKL activates an apoptotic JNK pathway opposed by RelA/p65. J Clin Invest (2008), in press.
  29. H. Epple, V. Cremasco, K. Zhang, D. Mao, G.D. Longmore, and R. Faccio. PLCgamma2 modulates integrin signaling in the osteoclast by affecting the localization and activation of Src kinase. MCB (2008) in press.
  30. Cremasco V, Graham DB, Novack DV, Swat W, Faccio R. Vav/Phospholipase Cgamma2-mediated control of a neutrophil-dependent murine model of rheumatoid arthritis. Arthritis Rheum. 2008 Sep;58(9):2712-22. PMID: 18759305

 

Roberta Faccio, Ph.D

Associate Professor

Department of Orthopaedics

Washington University

faccior@wustl.edu

Yalem Building 804

Phone: (314) 747-4602



 
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